Pulmonary Inflammation during Mechanical Ventilation of Patients with Healthy Lungs.

Pulmonary Inflammation during Mechanical Ventilation of Patients with Healthy Lungs. -HIgh tidal volumes versus LOwer tidal volumes in patients with HEalthy LUngs-

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON28818

Enrollment

Registered

2005-08-23

Start date

2003-11-01

Completion date

Unknown

Last updated

2024-02-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Patients that are scheduled for surgical procedure of > 5 hours.

Interventions

Mechanical ventilation using lower tidal volumes (6 ml/kg) and 10 cm H2O PEEP versus mechanical ventilation using traditional tidal volumes (12 ml/kg) and no PEEP. Broncholaveoalr lavage at T = 0 and

Eligibility

Inclusion criteria

Inclusion criteria: 1. Patients that are scheduled for surgical procedure of > 5 hours; 2. Healthy pulmonary condition; 3. 18 years of age; 4. informed consent.

Exclusion criteria

Exclusion criteria: 1. Sepsis or uncontrolled infection; 2. ALI/ARDS; 3. Pneumonia; 4. Steroid-use; 5. Diagnosis of asthma; 6. Pulmonary fibrosis; 7. Current thrombo-embolism; 8. On daily medication for COPD; 9. Mechanical ventilation for > 48 hours in the month prior to surgery; 10. Pneumonectomy/lebectomy; 11. Participation in another trial; 12. Previous randomisation in present trial.

Design outcomes

Primary

Measure	Time frame
1. Local levels of cytokines; 2. Neutrophil influx; 3. Activation of coagulation/inhibition of fibrinolysis; 4. Ex vivo stimulation of alveolar macrophages; 5. Systemic levels of biomarkers of lung injury.	—

Contacts

Public ContactM.J. Schultz

Meibergdreef 9

m.j.schultz@amc.uva.nl+31 (0)20 5669111

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)