insulin resistance, intermittent fasting
Conditions
Interventions
After the first study day, volunteers are randomly assigned to:
1. Two weeks standard diet
2. Two weeks of intermittent fasting.
After these two weeks, a study day as previously described will follow where after volunteers change diet (standard vs IF, or IF vs standard).
Sponsors
M.J.Serlie M.D. PhD
Dept. of Endocrinology and Metabolism
F5-167
Academic Medical Centre
Meibergdreef 9
1105 AZ AMSTERDAM
+31205669111
M.R.Soeters@amc.uva.nl
Eligibility
Inclusion criteria
Inclusion criteria: 1. Lean healthy male volunteers; 2. Age 18 - 35 years; 3. BMI 20-25 kg/m2; 4. Stable weight three months prior to study inclusion; 5. Normal oral glucose tolerance test (OGTT) using the ADA-criteria.
Exclusion criteria
Exclusion criteria: 1. Any medication; 2. DM II in first degree family members; 3. Hypertriglyceridemia or any other lipid metabolism disorder; 4. Intensive sports (> three times weekly); 5. Any medical disorder of significant relevance; 6. 'Breakfast-skipper'.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Insulin sensitivity of glucose metabolism. | — |
Secondary
| Measure | Time frame |
|---|---|
| Insulin sensitivity of lipid and protein metabolism. | — |
Contacts
Public ContactM.R. Soeters
Academic Medical Center (AMC) Department of Endocrinology & Metabolism, F5-162 P.O. Box 22660
Outcome results
None listed