Atrial fibrillation, implantable cardioverter defibrillator, home monitoring, coronary artery disease.
Conditions
Interventions
Patients with CAD and <LVEF 35% have a guideline indication for ICD therapy and will receive a single chamber ICD with an algorithm based rhythm recorder.
Sponsors
Academic Medical Center (AMC) Amsterdam
Eligibility
Inclusion criteria
Inclusion criteria: • Age between 65 and 80 years • CAD, evident from a) previous myocardial infarction or b) revascularization through PCI or CABG • LVEF 2 years
Exclusion criteria
Exclusion criteria: • Unwilling or unable to comply with the protocol • Unwilling to sign informed consent • Current atrial fibrillation • A history of atrial fibrillation • Previous catheter or surgical ablation for atrial fibrillation • Use of vitamin K antagonist or NOACs • Use of class 1 or 3 antiarrhythmic drugs for ventricular or supraventricular arrhythmia ` other than AF • Prosthetic heart valves • Dilated or hypertrophic cardiomyopathy • Congenital heart disease for which surgical correction was performed • Inherited arrhythmia syndrome • Active malignant disease • Use of antracyclins in the history • History of TIA, stroke or systemic embolism • Being pregnant or of child bearing potential • Life expectancy<2 years
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| the percentage of patients with AF at 1 or 2 years. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1) the time to 10% and 20% of patients with AF. 2) The burden as percentage/day of AF. 3) Occurrence of TIA, stroke or systemic embolism. 4) Cumulative incidence of appropriate and inappropriate ICD therapy. | — |
Contacts
Public ContactJ.R. Groot, de
Academic Medical Center-University of Amsterdam, F3-234
Outcome results
None listed