Flat colorectal cancer precursor lesions: epidemiological aspects and molecular analysis.

Flat colorectal precusor lesions in a Dutch population: epidemiological aspects, genotype-phenotype associations and molecular analysis.

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON28777

Enrollment

2500

Registered

2009-06-30

Start date

2008-02-01

Completion date

Unknown

Last updated

2024-02-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

colorectal cancer, precursor lesions, adenoma, flat, non-polypoid, high-risk population, family history of colorectal cancer

Interventions

1. Clinical data registration

2. Molecular analysis of polypoid vs. flat colorectal lesions.

Eligibility

Inclusion criteria

Inclusion criteria: Patients referred for routine colonoscopy with or without positive familiy history for colorectal cancer.

Exclusion criteria

Exclusion criteria: Molecular analysis: patients with inflammatory bowel disease.

Design outcomes

Primary

Measure	Time frame
1. Prevalence of flat colorectal lesions in a Dutch population; 2. Clinical characteristics (e.g. location of lesions, percentage of high-grade dysplasia or early cancer); 3. Molecular charcteristics (epigenetic: methylation status and genetic) of flat vs. polypoid colorectal lesions; 4. Prevalence of flat advanced colorectal cancers vs. polypoid advanced colorecal cancers: clinical features of these lesions (e.g. tumor stage); 5. Relation between serrated and adenomatous polyps.	—

Measure

Time frame

1. Prevalence of flat colorectal lesions in a Dutch population; 2. Clinical characteristics (e.g. location of lesions, percentage of high-grade dysplasia or early cancer); 3. Molecular charcteristics (epigenetic: methylation status and genetic) of flat vs. polypoid colorectal lesions; 4. Prevalence of flat advanced colorectal cancers vs. polypoid advanced colorecal cancers: clinical features of these lesions (e.g. tumor stage); 5. Relation between serrated and adenomatous polyps.

—

Secondary

Measure	Time frame
Prevalence and genotype and fenotype associations of flat colorectal lesions in patients at high-risk for colorectal cancer.	—

Contacts

Public ContactE. Rondagh

Postbus 5800

Eveline.Rondagh@INTMED.unimaas.nl+31-43-3875021

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)