(risk for) Cardiovascular disease
Conditions
Interventions
None listed
Sponsors
AmsterdamUMC, location AMC
Eligibility
Inclusion criteria
Inclusion criteria: - Healthy, male children under 12 years of age undergoing a circumcision - Parents / caregivers capable of giving written informed consent and able to comply with the requirements listed in the informed consent form.
Exclusion criteria
Exclusion criteria: - Childeren above 12 years of age - Unwillingness from the parents to let their child participate in the study - One or both parents who are not capable of reading and understanding the Dutch patient information letter - Parents who are not capable of giving written informed consent and able to comply with the requirements listed in the informed consent form - Contraindication for circumcision
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Define the environmental and biological factors that drive skin sodium accumulation according to the novel 3-compartment concept in the skin of children, and to investigate whether these factors are associated with risk factors for future cardiovascular disease. | — |
Secondary
| Measure | Time frame |
|---|---|
| The association between skin sodium accumulation and alterations in GAG metabolism and local immune cell infiltration. | — |
Contacts
Public ContactMarjet Oppelaar
Amsterdam UMC - location AMC
Outcome results
None listed