Stroke. Lacunar stroke. Cerebral small vessel disease
Conditions
Interventions
Single intravenous dose of 7500 IU of heparin, preceded and followed by withdrawal of 30 ml of blood.
Sponsors
University Hospital Maastricht,
PO Box 5800
6202 AZ Maastricht
The Netherlands
Eligibility
Inclusion criteria
Inclusion criteria: Patients: 1. First ever lacunar stroke patient (>18 years old) 2. Informed consent. 3. Absent of white matter hyperintensities OR extensive white matter hyperintensities on MR-scanning of the brain. Controls: 1. Healthy controls (>18 years old)
Exclusion criteria
Exclusion criteria: Patients: 1. Use of oral anticoagulants, heparin (derivates) of substances with ulcerogenic action (adrenal gland hormones or anti-rheumatic medication). 2. Allergy for heparin. 3. Arterial or venous thrombosis in the past three months. 4. History of hemorrhage in urogenital tract, digestive tract or intracerebral. 5. Personal history or family history of hemorrhagic diathesis 6. Malignant hypertension 7. Brain microbleeds on Gradient-echo of FFE - images (MRI) Controls: 1. Same as patients and, 2. History of cardiovascular events (stroke, myocardial infarction or periphery artery disease) 3. Known cardiovascular risk factors (hypertension, diabetes mellitus).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Levels of Tissue factor pathway inhibitor (TFPI) before and after administation of heparin in lacunar stroke patients and healthy controls. | — |
Contacts
Public ContactI.L.H. Knottnerus
University Hospital Maastricht Department of Neurology PO Box 5800
Outcome results
None listed