Measurement of changes in ventilation at various levels of inspired carbon dioxide with two methodes.

The hypercapnic ventilatory response measured with a rebreathing and steady-state apparatus in healthy subjects

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON28684

Enrollment

Registered

2017-03-06

Start date

2017-03-22

Completion date

Unknown

Last updated

2025-03-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

healthy subjects

Interventions

None listed

Eligibility

Inclusion criteria

Inclusion criteria: healthy, adult aged between 18 and 65

Exclusion criteria

Exclusion criteria: history of cardio-pulmonary disease, neuro(muscular) disease, and/or kyphoscoliosis; unable to understand and read the English or Dutch language; drug abuse; use of respiratory stimulants or depressant; and pregnant women

Design outcomes

Primary

Measure	Time frame
The main study endpoint is the reproducibility of the measurements. Sensitivity slope (L/min per kPa) of the curve is calculated by means of linear regression. To assess the repeatability of both methods, the ICC is calculated between the paired CO2 sensitivity slopes of the first and second rebreathing measurement and between the first and second steady-state measurement	—

Secondary

Measure	Time frame
Secondary endpoints are: -The experiences of the subjects with both measurements - Duration of the measurements - Costs of the method (sum of the costs of the various part of each method + costs of one long function analyst performing the measurement) - minimal CO2 in rebreathing technique	—

Contacts

Public ContactD.C. Mannée

Nijmeegsebaan 31

denise.mannee@radboudumc.nl+31 (0) 6 15 43 33 75

Outcome results