A double blind placebo controlled trial comparing the effect of repetitive Transcranial Magnetic Stimulation (rTMS) of two treatment strategies for Auditory Verbal Hallucinations (AVH).

Is fMRI guided rTMS superior to rTMS directed to the left temporoparietal (TP) and sham in the treatent of AVH?

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON28652

Enrollment

100

Registered

2009-09-14

Start date

2008-01-01

Completion date

Unknown

Last updated

2024-02-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

auditory verbal hallucinations schizophrenia repetitive transcranial magnetic stimulation

Interventions

rTMS treatment 15 treatment sessions of 20 minutes in a frequency of 1 hertz and an individual motor threshold of 90%.

Eligibility

Inclusion criteria

Inclusion criteria: 1. Medication resistant AVH; 2. AVH more than once per hour; 3. Written informed consent.

Exclusion criteria

Exclusion criteria: 1. Epilepsy; 2. Pregnancy; 3. Drug/alcohol abuse; 4. Daily use of benzodiazepines; 5. Use of anti-epileptic agents; 6. Claustrophobia; 7. Metal in or around the body that cannot be removed.

Design outcomes

Primary

Measure	Time frame
Auditory Hallucination Rating Scale.	—

Secondary

Measure	Time frame
1. Positive items of the Positive And Negative Symptoms Scale (PANSS); 2. Psychotic symptom rating scales (PSYRATS).	—

Contacts

Public ContactC.W. Slotema

Stadhoudersplantsoen 2

c.slotema@parnassia.nl+31 (0)70 3918600

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)