Influence of intravenous versus oral administration, arterial versus venous sampling and gender on pharmacokinetic-pharmacodynamic modelling of morphine and morphine-6-glucuronide-induced pain relief in healthy volunteers.

Influence of intravenous versus oral administration, arterial versus venous sampling and gender on pharmacokinetic-pharmacodynamic modelling of morphine and morphine-6-glucuronide-induced.

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON28632

Enrollment

Registered

2005-09-06

Start date

2005-11-01

Completion date

Unknown

Last updated

2024-02-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Post-operative pain

Interventions

Drug administration (blinded): morphine or M6G.

Eligibility

Inclusion criteria

Inclusion criteria: 1. Healthy volunteers; 2. Aged 18+.

Exclusion criteria

Exclusion criteria: 1. BMI>30; 2. Pregrancy or lactation; 3. Presence of medical disease; 4. Presence of psychiatric disease; 5. Allergy to study medication; 6. History of drugs or alcohol abuse.

Design outcomes

Primary

Measure	Time frame
Pain relief related parameters (VAS to heat pain) in males vs females.	—

Secondary

Measure	Time frame
PK parameters.	—

Contacts

Public ContactAlbert Dahan

Leiden University Medical Center (LUMC), Department of Anesthesiology, P.O. Box 9600

a.dahan@lumc.nl+31 (0)71 5262301

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)