hyponatraemia, elderly, sodium level, Thiazide dutch: hyponatremie, ouderen, natrium, thiazide
Conditions
Interventions
All subjects included in this controlled experiment will receive a single dose of Hydrochloorthiazide 50 mg. After that they will be monitored for 24hours
Sponsors
Bert-Jan van den Born
Academic Medical Centre
Dept. Vascular Medicine
Meibergdreef 9 F4-255
the Netherlands
tel:+31 20 5665956
Eligibility
Inclusion criteria
Inclusion criteria: 1. Age 60-80 years; 2. Previously admitted with thiazide-induced hyponatraemia; 3. Patients must be willing and medically able to discontinue anti-hypertensive therapy six weeks before the study and for the duration of the study; 4. Patients must be willing to be admitted for 24 hours and must be medically able to take the study medication; 5. Patients must be willing to give informed consent.
Exclusion criteria
Exclusion criteria: 1. Other causes for hyponatraemia (e.g. heart failure, pulmonary disease, medication associated with hyponatraemia); 2. Renal dysfunction (estimated clearance 140/90 mmHg while using 3 or more anti-hypertensive drugs)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Effect of a single oral dose hydrochloorthiazide 50 mg intake on the serum and urine sodium, serum ADH, prostaglandin E2 and urinary aquaporin-2 excretion in elderly patients (aged 60-80 years) with previous thiazide-induced hyponatraemia (sodium <125 mmol/l) without another cause for their hyponatraemia and matched controls receiving a thiazide diuretic without hyponatraemia. Urinary hydrochlorothiazide concentrations are measured to analyse differences in thiazide metabolism. The response to ADH will be assessed by expression of AVPR2 in a cell-culture and determine its activity by measurement of cAMP | — |
Secondary
| Measure | Time frame |
|---|---|
| To identify (elderly) patients who are at risk of thiazide induced hyponatraemia | — |
Contacts
Public ContactNanne Frenkel
Academic Medical Centre Dept. Vascular Medicine
Outcome results
None listed