Brain tumours: low-grade gliomas and meningiomas
Conditions
Interventions
this is a longitudinal observational study. No intervention is applied by the researchers, only assessments.
- The patient groups will get an EEG recording, language assessment, a few neuropsycholog
Sponsors
Center for Language and Cognition Groningen, Faculty of Arts, Rijksuniversiteit Groningen
Eligibility
Inclusion criteria
Inclusion criteria: Low-grade glioma group: - Diagnosis of a presumed low-grade glioma in the language dominant hemisphere - Tumour is untreated, planned to undergo awake brain surgery - In case of epilepsy, seizures under control with anti-epileptic drugs (less than 6 seizures in the previous year and on anti-epileptic monotherapy or polytherapy) - Between 18 and 75 years old Low-grade meningioma group: - Diagnosis of a presumed low-grade supratentorial meningioma in the language dominant hemisphere - Tumour is untreated, planned to undergo brain surgery - In case of epilepsy, seizures under control with anti-epileptic drugs (less than 6 seizures in the previous year and on anti-epileptic monotherapy or polytherapy) - Between 18 and 75 years old Control group without brain injury: Comparable to the patient groups with respect to age, gender and education - Right-handed - Between 18 and 75 years old
Exclusion criteria
Exclusion criteria: For all 3 groups: - Non-native speaker of Dutch or insufficient command of the Dutch language - History of a medical, neurological or psychiatric condition known to affect language or cognitive functioning - (History of) substance abuse - Use of medication known to influence EEG, language or cognitive functioning, other than antiepileptic drugs - Previous brain surgery or radiation therapy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| - Language abilities of low-grade glioma and meningioma patients before surgery, shortly after surgery, and at the long-term follow-up. - The relation between language functioning and resting-state EEG characteristics in brain tumour patients. - Pre-operative EEG characteristics that predict language outcome after brain tumour surgery. | — |
Secondary
| Measure | Time frame |
|---|---|
| - Functional network characteristics of resting-state brain activity that are associated with specific linguistic deficits. - Associations between language and performance in other cognitive domains. - The relation between the severity of the language disorder and the quality of life in brain tumour patients before and after surgery. | — |
Contacts
Public ContactNienke Wolthuis
Harmony Building 1313.0350
Outcome results
None listed