Complex Regional Pain Syndrome Carpal Tunnel Syndrome
Conditions
Interventions
None listed
Sponsors
Center for Pain Medicine Department of Anesthesiology Erasmus MC University Medical Center Rotterdam
Eligibility
Inclusion criteria
Inclusion criteria: In order to be eligible to participate in this study, a subject must meet all of the following criteria: Patients with CRPS: - Age = 18 years - Diagnosis of CRPS according to the new IASP (International Association for the Study of Pain) criteria for diagnosis of CRPS - One upper extremity is affected Patients with CTS - Age = 18 years - Diagnosis of CTS confirmed with electromyography
Exclusion criteria
Exclusion criteria: A potential subject who meets any of the following criteria will be excluded from participation in this study: Patients with CRPS: - Age < 18 years - More than one extremity affected - History of auto-inflammatory or autoimmune disease - Current treatment with glucocorticoids or treatment within the last 6 months. - Current treatment with immune-modulating medicines, like bisphosphonates, or treatment within the last 6 months. - Suspected or confirmed pregnancy. - Dementia - Insufficient understanding of the Dutch language - Allergy to dexamethasone Patients with CTS - Undergone CTS treatment - (Consideration of) diagnosis of CRPS in history - Age < 18 years - History of auto-inflammatory or autoimmune disease - Current treatment with glucocorticoids or treatment within the last 6 months. - Current treatment with immune-modulating medicines, like bisphosphonates, or treatment within the last 6 months. - Suspected or confirmed pregnancy. - Dementia - Insufficient understanding of the Dutch language - Allergy to dexamethasone
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Functioning of the HPA axis; for optimal examination of functioning of the HPA axis various measurements of cortisol levels will be used. •Cortisol awakening response (CAR) •Dexamethasone suppression test (DST) •Hair cortisol | — |
Secondary
| Measure | Time frame |
|---|---|
| • Cortisol binding globulin • Level of soluble IL2-receptor in blood • Biomarkers; sCD163 and sCD206 • Psychosocial determinants: questionnaires focusing on the severity of the pain, awareness of disease and perception, perceived health and quality of life, coping, anxiety and depression will be used. • Cognition: a neuropsychology test battery of ten cognitive tests will be used. • General parameters for all participants: gender, age, medical history, medication use, allergies, weight (kg), length (cm), side of affected limb, date of diagnosis, smoking, use of alcohol, drugs and/or anabolic/androgenic steroids, and socioeconomic status (using level of education as indicator). • Additional parameters for CRPS patients: - CRPS severity score - Presence of neuromodulation; if present also specification of type of neuromodulation | — |
Contacts
Public ContactCorinne van den Berg
Erasmus MC
Outcome results
None listed