None
Conditions
Interventions
8-16 volunteers will be included in Part 1.
In part 1 they will participate during 4 study days. In 2 study days their EtCO2 will be clamped, in 2 study days there will be ambient air and pain measu
Sponsors
Leiden University Medical Center
Eligibility
Inclusion criteria
Inclusion criteria: Healty volunteers in the age of 18-45 with a BMI between 18-30 kg/mm2. There has to be no ECG abnormalities, no clinical laboratory abnormalities, no clinically significant disease. All subjects must sign the written informed consent.
Exclusion criteria
Exclusion criteria: History of: Alcohol abuse, anxiety disorder, psychiatric diseases, drug abuse, smoking,bleeding disorders, medical history. allergic reactions, malignancy, malignant hyperthermia. Other exclusion criteria is family members or allergic reactions.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Determine the respiratory response of low and high doses of doxapram in conjunction with a low dose of opioids in healty volunteers; 2. Determine the respiratory response of low and high doxapram in conjunction with a low dose of opioids and hypercapnia in healty volunteers. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Determine the respiratory response of low and high doses of doxapram in conjunction with a high dose of opioids in healty volunteers; 2. Evaluate the tolerability of doxapram in conjunction with a low and high dose of opioids in healty volunteers; 3. Evaluate the PK-PD relationship of the respiratory responses of Doxapram in conjunction with a low and high dose of opioids in healty volunteers. | — |
Contacts
Public ContactAlbert Dahan
Leiden University Medical Center (LUMC), Department of Anesthesiology, P.O. Box 9600
Outcome results
None listed