'Gastric emptying' 'amino acid absorption'
Conditions
Interventions
Participants will ingest three 400-mL test foods containing 20g pea protein:
- Protein in suspension: 5% (5g/100g) protein suspension unheated
- Protein in suspension: 5% (5g/100g) protein suspension
Sponsors
Wageningen University
Eligibility
Inclusion criteria
Inclusion criteria: • Male • Age 18 – 55 y • Apparently healthy • Normal-weight (BMI 18.5 – 25)
Exclusion criteria
Exclusion criteria: • Pea protein allergy (self-reported) • Gastric disorders or regular gastric complaints such as heart burn • Use of medication which alters the normal functioning of the stomach, such as: o medical drug use that influences the GI tract’s normal function, e.g. the motility, pH etc: among others use of proton pump inhibitors, antacids, anti-depressants etc. (judged by our study doctor) o Medical drug use that influence the GI tract’s microbiota: e.g. antibiotic use within 1 months prior to the pre-study screenings day (judged by our study doctor) • Use of recreational drugs within 1 month prior to the pre-study screenings day • Alcohol consumption of more than 14 glasses/week • Use of protein supplements during the study • Following a medical diet • Participating in other biomedical research during the study period • Smoking (>2 cigarettes a week) • Having donated blood in the two months preceding the first visit • Hb value below 8.4 mmol/L (as measured with finger-prick method) • Having a contra-indication to MRI scanning (including, but not limited to): ? Intraorbital or intraocular metallic fragments ? Ferromagnetic implants ? Claustrofobia • Not having a general practitioner or unwillingness to share chance findings of pathology with the general practitioner • Being an employee or student of the Division of Human Nutrition and health
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Post-prandial serum amino-acid concentration 2. Gastric emptying rate | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Postprandial glucose and insulin levels 2. Gastric layer formation and other product instabilities if visible 3. Fullness, bloating, nausea ratings obtained after each MRI measurement | — |
Contacts
Public ContactJulia Roelofs
Wageningen University & Research
Outcome results
None listed