Extrahepatic Biliary Atresia, Chlamydia infection
Conditions
Interventions
Mothers will undergo one venapuncture. Biliary atrsia patients and controls will not be exposed to extra interventions.
Sponsors
Paul Fockens, MD, PhD
Department of Gastroenterology and Hepatology
Academic Medical Center
The Netherlands
Eligibility
Inclusion criteria
Inclusion criteria: • Biopsy proven biliary atresia • Underwent Kasai operation • Liver tissue stored at the Department of Pathology • Outpatient follow up in the Academic Medical Center, Amsterdam or University Medical Centre Groningen • Younger than 12 years •Informed consent of custodial parent(s) or guardian, for inclusion of their child • Informed consent of the mother for the withdrawal of maternal blood for ELISA on Chlamydia
Exclusion criteria
Exclusion criteria: • Patients with embryonic biliary atresia • Older then 12 years
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The presence of Chlamydia IgA antibody in serum of Dutch patients with biliary atresia, compared to the control group. The presence of Chlamydia in liver tissue (liver biopsy and fibrotic remnant obtained during Kasai operation) of BA patients as compared to controls, examined by PCR as well as Chlamydia-specific staining by immunohistochemistry. | — |
Secondary
| Measure | Time frame |
|---|---|
| The presence of Chlamydia IgA antibody in serum of mothers of patients with biliary atresia, compared to the presence of Chlamydia IgA antibody in serum of mothers of the control group and the presence of Chlamydia IgA antibody in the general population. | — |
Contacts
Public ContactLiesbeth Vries, de
Outcome results
None listed