ST-segment elevation myocardial infarction (STEMI), Acute Coronary Syndrome (ACS), myocardinfarct
Conditions
Interventions
Obtainment of blood samples (these repeated procedures will be in alignment with the standard blood sampling as part of standard diagnostic work-up as much as possible).
Sponsors
Erasmus Medical Center, Rotterdam
Prof. Eric Boersma, MSc, PhD, FESC, Professor of clinical epidemiology of cardiovascular diseases.
Eligibility
Inclusion criteria
Inclusion criteria: The following inclusion criteria will be applied (all criteria should apply): 1. Men and women, aged from 18 to 70 years, capable of understanding the study content of and willing to provide written informed consent at admission to the hospital; 2. Diagnosis of STEMI, according to the guidelines of the European Society of Cardiology (ESC) 2008. The diagnosis is defined as a history of chest pain / discomfort lasting for 10 ¨C 20 minutes or more (not responding fully to nitroglycerine) with persistent ST segment elevation and elevated markers of myocardial necrosis. Other causes of chest pain / discomfort must be ruled out by the cardiologist; 3. Symptom duration <6h; 4. Blood is drawn before PCI.
Exclusion criteria
Exclusion criteria: Patients with at least one of the following characteristics will be excluded: 1. Myocardial ischemia precipitated by a condition other than atherosclerotic coronary artery disease; 2. Admission for an ACS and / or interventions < 6 months; 3. Diabetes Mellitus; 4. Other existing heart conditions; 5. Clinically significant renal disturbance (GFR (MDRD) ≤ 30 mL/min/1.73m2) or known renal disease; 6. Severe inflammatory or current malignant disease; 7. Darkly coloured skin; 8. Auto-immune / connective tissue disease; 9. Aorta dissection; 10. Comatose at admission to the CCU; 11. Undergoing PCI for STEMI as a result of complications during elective procedures.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary endpoints are serial measurements of a) skin AF by the AGE reader® and b) value of AGEs as measured in serum. Furthermore, cardiac enzymes levels will be assessed repeatedly to determine the area under the curve for estimation of the infarct size. | — |
Contacts
Public ContactN. Buljubasic
Outcome results
None listed