patients with osteoarthritis and sarcopenic obesity
Conditions
Interventions
The intervention group will follow a supervised (by a physiotherapist) exercise intervention of 6 weeks (twice a week) with progressive strength training and aerobic training. This will be combined wi
Sponsors
None listed
Eligibility
Inclusion criteria
Inclusion criteria: • scheduled for THA or TKA with a waiting period of minimal 6 weeks (which is the usual waiting period) • OA as reason for THA or TKA • Having obesity (BMI =30 kg/m2) • Having muscle weakness (Men: Hand Grip Strength (HGS) 15sec for five rises) 12 • Adequate cognitive functioning (the patient is capable to understand instructions and to per-form the screening) • Age 18 years or older
Exclusion criteria
Exclusion criteria: • Unable to understand Dutch • Patients diagnosed with dementia • Patients who are unable to exercise due to comorbidities/ contra-indications. Absolute con-tra-indications for exercise are listed in the Dutch guideline for OA 13 and in the ACSM's Guidelines for Exercise Testing and Prescription 14. See appendix 1 for additional information about contraindications and considerations when prescribing exercises to older people with comorbidity. • Patients with severe renal insufficiency or an eGFR<30 (estimated Glomerular Filtration Rate)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Feasibility is assessed by adherence to the treatment, inclusion and dropout rate, adverse events and the patient appreciation and motivation, as assessed by questionnaires. | — |
Secondary
| Measure | Time frame |
|---|---|
| Preliminary effectiveness is assessed by measuring physical functioning (timed up and go test, hand grip strength, walking speed/ six-minute walk test, chair rise time test, questionnaires), body composition (BIA/ DEXA) and inflammation (CRP, IL-6) before and after 6 weeks of intervention. In addition, postoperative inpatient complications, recovery of physical functioning and length of hospital stay will be assessed. Furthermore, nutritional intake (3-day food diary) and physical activity (by accelerometer) will be measured. | — |
Contacts
Public ContactEllen Oosting
Gelderse Vallei Hoispital
Outcome results
None listed