Feasibility study to use new techniques/biomarkers to measure oxidative stress and the influence of vitamin E&C on these parameters in patienst suffering from intermittent claudication.

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON28549

Enrollment

Registered

2005-10-10

Start date

2002-01-01

Completion date

Unknown

Last updated

2024-02-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Patients suffering from intermittent claudication are followed during exercise on a standard treadmill. Experiments are repeated after antioxidant suppletion (vitamins E & C).

Interventions

Patients will receive antioxidant supplementation with high concentrations of vitamin E (200 mg/day) and vitamin C (1000 mg/day) during 4 weeks.

Eligibility

Inclusion criteria

Inclusion criteria: Stable (more than 6 months regarding subjective walking distance) patients with claudication intermittens.

Exclusion criteria

Exclusion criteria: Patients with pre-existing renal dysfunction and those not able to perform a standard walking test.

Design outcomes

Primary

Measure	Time frame
Levels of 'new' parameters of oxidative stress like isofuranes and halogenated phospholipids are determined. Also vascular parameters (fibrinogen, PAI-1 activity etc) and endothelial damage parameters (soluble thrombomodulin, von Willebrand factor etc) are determined. New techniques like multivariate NMR will be determined for their usefulness in the above mentioned type of studies.	—

Contacts

Public ContactH.L. Vader

P.O. Box 7777

h.vader@mmc.nl+31 (0)40 8888900

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)