neonatal thrombocytenia platelet transfusion
Conditions
Interventions
Randomization of patients between platelet trasnfusion support with standard plasma aphaeresis platelet concentrate: 10 * 109 platelets/ kg body weight in a volume of 10 mL/ kg body weight (Arm A), o
Sponsors
ErasmusMC - Sophia
Eligibility
Inclusion criteria
Inclusion criteria: 1. Neonates, <28 days corrected age, admitted to the neonatal or pediatric intensive care (NICU/PICU) with thrombocytopenia that require a platelet transfusion according to the clinical guidelines; 2. Written informed consent by parent(s) or caregiver(s).
Exclusion criteria
Exclusion criteria: 1. Neonatal allo-immune thrombocytopenia (NIATP); 2. Maternal ITP; 3. Therapeutic platelet transfusion during surgery; 4. Platelet transfusion during red blood cell exchange; 5. Platelet transfusion during extracorporal membrane oxygenation (ECMO).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1 hour platelet transfusion increment. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. 24 hour platelet transfusion increment; 2. Bleeding grade ≥ 2; 3. Thrombosis grade ≥2; 4. Adverse transfusion reactions; 5. Transfusion requirement and interval to the next platelet transfusion; 6. Donor exposure. | — |
Contacts
Public ContactA.J. Willemze
Erasmus MC - Sophia Childrens Hospital Dept. of Oncology/Hematology Dr. Molewaterplein 60
Outcome results
None listed