necrotizing enterocolitis
Conditions
Interventions
n.a.
Sponsors
n.a.
Eligibility
Inclusion criteria
Inclusion criteria: All children admitted to the neonatology department, which are - born at a gestational age of = 30 weeks - and/or born with a birth weight of = 1000 gram, and parent consent in participating in the study.
Exclusion criteria
Exclusion criteria: Abdominal disease such as abdominal wall defects, congenital intestinal atresia, as well as major congenital heart defects (e.g. Tetrology of Fallot).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Development of necrotizing enterocolitis | — |
Secondary
| Measure | Time frame |
|---|---|
| Neonatal: faecal microbiota, faecal human DNA methylation pattern (shedded enterocytes and lymphocytes), faecal bile salts acids, faecal SCFA and iAP, iAP expression in the margins of the resection specimens, urine metabolome, cerebral and intestinal tissue oxygen saturation (as measured with NIRS), peak systolic flow velocity and the mean end-diastolic flow velocity of the superior mesenteric artery and a branch of the medial cerebral artery assessment using Echo Doppler, serum IMA, serum (i)AP, T1/T2 cytokine ratio in umbilical cord blood, iAP in surgical resection material. Mother: microbiota in mother's milk, placenta and rectal microbiota; amniotic fluid in case of caesarean, validated diet questionnaire ('Wat een Nederland' questionnaire as used by RIVM) | — |
Contacts
Public ContactDaphne Klerk
University Medical Center Groningen
Outcome results
None listed