Obsessive Compulsive Disorder Exposure in vivo with response prevention Behaviour therapy Treatment experience Cognitive therapy Antidepressants SSRI's Fluvoxamine Algorithm Obssieve Compulsieve stoornis Exposure in vivo met repons preventie Gedragstherapie Cognitieve therapie Therapie ervaring Antidepressiva SSRI's Fluvoxamine Behandelalgoritme
Conditions
Interventions
First Phase:
12-week exposure in vivo with response prevention (ERP). Participants were randomized to:
1. Therapist-controlled ERP performed by experienced behavior therapists
2. Therapist-controlled ERP performed by clinical psychology students
3. Self-controlled ERP performed by experienced behavior therapists
4. Self-controlled ERP performed by clinical psychology students
Second Phase:
Non-responders of the first phase were randomised to 12 weeks treatment with:
1. Cognitive therapy
2. Fluvoxamine.
Sponsors
No sponsoring
Eligibility
Inclusion criteria
Inclusion criteria: 1. Main diagnosis of Obsessive Compulsive Disorder according to DSM-IV 2. Duration at least one year 3. Age > 16 years 4. Informed Consent 5. No treatment for OCD elsewhere 6. Willing and able to stop with antidepressant and/or antipsychotic treatment.
Exclusion criteria
Exclusion criteria: 1. Obsessions only 2. Suicidal intention 3. Organic brain disease 4. Past or present psychotic disorder 5. Psychoactive substance use disorder 6. Borderline or anti-social personality disorder 7. Pregnancy 8. CBT 6 months before inclusion
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Yale-Brown Obsessive Compulsive Scale (Y-BOCS), measured by trained and weekly supervised interviewers who are blind to the treatment condition of the patients. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Padua Inventory-Revised (PI-R) 2. Anxiety Discomfort Scale (ADS) 3. Beck Depression Inventory (BDI) | — |
Contacts
Public ContactA.J.L.M. Balkom, van
VU University Medical Center Department of Psychiatry / GGZ Buitenamstel
Outcome results
None listed