Intracerebraal hematoom CVA Beroerte Trombocyten transfusie Intracerebral haemorrhage Stroke Platelet transfusion Anti-platelet therapy
Conditions
Interventions
- 95 patients receive platelet transfusion as soon as possible within 6 hours after onset
- 95 patients receive standard care
Platelet transfusion consists of a single gift of 5 or 10 donor units de
Sponsors
AMC
Eligibility
Inclusion criteria
Inclusion criteria: 1. Age > 18 years 2. Non-traumatic, primary, supratentorial ICH 3. Haematoma volume > 150 cc 4. GCS score 8-15 5. Anti-platelet therapy for at least the previous 7 days 6. Transfusion can be started < 6 hrs after onset 7. Transfusion can be started < 1,5 hrs after CT 8. mRankin scale score before ICH 0 or 1 9. Informed consent obtained
Exclusion criteria
Exclusion criteria: 1. Bleeding pattern on CT suggestive of AVM or aneurysm 2. Haematoma evacuation planned < 24 hrs 3. Intraventricular haemorrhage (sedimentation in posterior horns is allowed) 4. Previous adverse reaction to platelet transfusion 5. Known use of vitamine K antagonists 6. Known thrombocytopenia < 100 x 109/l 7. History of coagulopathy 8. Previously legally incompetent adults prior to stroke 9. Death appears imminent
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Poor outcome defined as a modified Rankin Scale (mRS) score 4-6 after 3 months. | — |
Secondary
| Measure | Time frame |
|---|---|
| - Haematoma growth on CT in the first 24 hours - Complications of platelet transfusion - Whether the CTA "spot sign" can predict primary outcome - Whether the CTA "spot sign" can predict haematoma enlargement on CT - Survival rate and level of physical disability at three months - Functional health at three months using the full ordinal scoring range of the mRS - Costs | — |
Contacts
Public ContactIrem Baharoglu
Department of Neurology Academic Medical Center University of Amsterdam
Outcome results
None listed