Resuscitation Preterm infants Oxygen
Conditions
Interventions
Based on randomization, stabilisation after birth will be initiated with a FiO2 of either 1.0 or 0.3, after which FiO2 will be titrated based on oxygen saturation. SpO2 will be measured continuously a
Sponsors
Leiden University Medical Center
Eligibility
Inclusion criteria
Inclusion criteria: Preterm infants of 24-30 weeks of gestation will be randomized to start stabilisation after birth with a FiO2 of either 1.0 or 0.3, after which FiO2 will be titrated based on oxygen saturation.
Exclusion criteria
Exclusion criteria: Congenital abnormality or condition that might have an adverse effect on breathing or ventilation, if these conditions are not already diagnosed before birth, including: congenital diaphragmatic hernia, trachea-oesophageal fistula or cyanotic heart disease.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The main study parameter is respiratory effort, expressed as: -Average respiratory minute volume in the first 5 minutes after birth | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary study parameters are; - Interaction of respiratory minute volume in the first 5 minutes after birth with time - Average tidal volumes in the first 5 minutes after birth - Interaction of tidal volumes in the first 5 minutes after birth with time - Average rate of rise to maximum tidal volumes in the first 5 minutes after birth - Interaction of rate of rise to maximum tidal volumes in the first 5 minutes after birth with time - Percentage of recruitment breaths with tidal volumes above 8 ml/kg in the first 5 minutes after birth - Concentration of 8-iso-prostaglandin F2á(25), an oxidative stress metabolite associated with hyperoxia in blood. This blood sample will be taken together with the sample for measuring standard blood analyses, so that the infant will not be exposed to an extra venepuncture or capillary puncture. | — |
Contacts
Public ContactJanneke Dekker
LUMC
Outcome results
None listed