Patients with a first or subsequent transfusion event, stratified for patients with alloantibodies after a previous transfusion. (NLD: Trefwoorden: Red blood cell antibodies, Erytrocyten antistoffen Preventive matching, Preventief matchen).
Conditions
Interventions
Patients are randomly assigned to receive standard ABO-D matched or extended (C, E, c, e, K, Fya, Jka and S) matched RBC transfusions.
Sponsors
Sanquin Bloodbank Southwest Region
Eligibility
Inclusion criteria
Inclusion criteria: The general transfusion population >18 years requiring an elective RBC transfusion.
Exclusion criteria
Exclusion criteria: 1. Patients younger than 18 years; 2. Patients with an a priori indication for matched transfusions; 3. Patients with a positive direct antiglobulin test; 4. Patients who, based on the local pre-operative blood-ordering list, require more than 4 units during surgery; 5. Incapacitated subjects or patients who cannot understand the information.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of alloimmunization in transfusion patients through preventive donor matching for the clinically relevant blood cell antigens compared to standard matching in patients stratified for high risk and random risk for alloimmunization. | — |
Secondary
| Measure | Time frame |
|---|---|
| Cost-analysis for current serologic screen and match strategy compared to preventive matching strategy in the two strata of patients. Health benefits: investigate transfusion and/or other medical treatment delay in case of RBC alloimmunization. Clinical and genetic factors associated with alloimmunization. | — |
Contacts
Public ContactH. Schonewille
Sanquin Bloedbank Southwest region Plemanslaan 1a
Outcome results
None listed