The effect of ketamine on inhibitory pain mechanimsm in the central nervous system in chronic pain patients.

Influence of S(+)-ketamine on Diffuse Noxious Inhibitory Control (DNIC) and offset analgesia (OA) in chronic pain patients (neuropathic pain, complex regional pain syndrome type 1, fibromyalgia) and healthy volunteers.

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON28485

Enrollment

Registered

2009-09-10

Start date

2009-01-09

Completion date

Unknown

Last updated

2024-02-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Complex Regional Pain Syndrome type 1, fibromyalgia and neuropathic pain patients.

Interventions

The administration of intravenous S(+)-ketamine.

Eligibility

Inclusion criteria

Inclusion criteria: 1. Patients diagnosed with CRPS-1, small-fiber neuropathy of fibromyalgia, according to the guidelines of the IASP or other professional pain societies; 2. A pain score of 5 or higher; 3. Age between 18 and 75 years; 4. Being able to give written informed consent.

Exclusion criteria

Exclusion criteria: 1. Unable to give written informed consent; 2. Medical disease such as renal, liver, cardiac, vascular (incl. hypertension) or infectious disease; 3. Increased intracranial pressure; 4. Epilepsy; 5. Psychosis; 6. Glaucoma; 7. A history of cerebro-vascular accident 30).

Design outcomes

Primary

Measure	Time frame
1. Presence of DNIC; 2. Presence of offset analgesia; 3. Effect of ketamine on DNIC and offset analgesia.	—

Secondary

Measure	Time frame
Adverse events.	—

Contacts

Public ContactAlbert Dahan

Leiden University Medical Center (LUMC), Department of Anesthesiology, P.O. Box 9600

a.dahan@lumc.nl+31 (0)71 5262301

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)