Hyperplastic polyposis syndrome, hyperplastic polyp
Conditions
Interventions
Patients with HPS will be evaluated by colonoscopy using a prototype endoscopic imaging system which integrates WLE and NBI in one unit (Spectrum system, Olympus, Tokyo, Japan). All segments of the co
Sponsors
Academic Medical Center (AMC), Department of Gastroenterology
Eligibility
Inclusion criteria
Inclusion criteria: All patients presenting, or under surveillance at the Endoscopy Department of the AMC with: 1. >10 HPs found at colonoscopy, or 2. >5 HPs proximal to the sigmoid colon, or 3. Any number of HPs occurring proximal to sigmoid colon in an individual who has a first-degree relative with HPS.
Exclusion criteria
Exclusion criteria: Exclusion criteria are 1. History of inflammatory bowel disease, 2. Severe coagulopathy, 3. Age less than 18 years and 4. Insufficient bowel preparation (<90% of colonic mucosa visible).
Design outcomes
Secondary
| Measure | Time frame |
|---|---|
| Furthermore, the surface pit pattern of the detected lesions on NBI will be used to obtain the overall accuracy (representing sensitivity and specificity) of this technique, by using the histological diagnosis as the gold standard diagnosis. Moreover, the prevalence and distribution of HPs, SAs, MPs and adenomas in this patient population will be described | — |
Primary
| Measure | Time frame |
|---|---|
| The sensitivity of WLE will be compared to that of NBI for the detection of polyps and cancer in the colon. The sensitivity of each technique will be calculated as the number of lesions detected during the first inspection, divided by the total number of lesions detected by both inspections. | — |
Contacts
Public ContactK.S. Boparai
Academic Medical Center (AMC), Department of Gastroenterology
Outcome results
None listed