Patients with refractory hypertension and patients with combined hypertension and paroxysmal or persistent atrial fibrillation. Patients who are accepted for renal denervation or combined pulmonary vein isolation and renal denervation according to routine clinical practice are eligible for this study. Patiënten met refractaire hypertensie en patiënten met gecombineerde hypertensie en paroxysmale of aanhoudende atrim fibrileren. Patiënten die worden geaccepteerd voor renale denervatie of ge
Conditions
Interventions
-RNS-checked RDN
- RNS-guided RDN
Sponsors
Department of Cardiology, Isala
Eligibility
Inclusion criteria
Inclusion criteria: - Patients with refractory hypertension and patients with combined hypertension and paroxysmal or persistent atrial fibrillation. - Age 18-80 years - Glomerularfiltrationrate >45 mL/min - No history of renal artery stenosis
Exclusion criteria
Exclusion criteria: - Type 1 diabetes mellitus - Contraindication to chronic anticoagulation therapy or heparin. - Primary pulmonary hypertension. - Known secondary cause of hypertension - Renal artery stenosis >50% of the arterial lumen, or renal artery lumen ¡Ü3 mm. - Dual or triple ipsilateral renal artery ostia.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Main study parameter will be the arterial blood pressure response to renal nerve stimulation (RNS) prior to renal denervation (RDN) and absence of blood pressure rise in response to pacing in the renal artery after renal denervation (RDN). | — |
Secondary
| Measure | Time frame |
|---|---|
| Blood pressure at 3, 6, 12 months after the intervention, and change in blood pressure compared to measurement before the intervention | — |
Contacts
Public ContactSonja Postma
Dokter Stolteweg 96
Outcome results
None listed