Obesity, diabetes type II, cardiovascular diseases
Conditions
Interventions
None listed
Sponsors
Investigator initiated
Eligibility
Inclusion criteria
Inclusion criteria: Inclusion criteria parents: - Capability of the parents to comply with study protocol. - Knowledge of the Dutch language. Inclusion criteria newborns: - Healthy and full-term infants (gestational age = 36 weeks). - Children with a neonatal period without severe asphyxia (defined as a Apgar score <3 after 5 minutes), and no serious disease such as long-term artificial ventilation and oxygen supply, broncho pulmonary dysplasia or other lung disease - Written informed consent from both parents.
Exclusion criteria
Exclusion criteria: Exclusion criteria parents: - Maternal use of corticosteroids during pregnancy. - Pregnant women/parents known to have other significant medical condition (including during pregnancy) that might interfere with the study or known to affect intra-uterine growth as per investigator’s clinical judgment. Exclusion criteria newborns: - Confirmed intra-uterine infection. - Infants with chromosomal disorders, known syndromes and serious dismorphic symptoms suggestive for a (yet unknown) syndrome. - Any endocrine or metabolic disorder such as diabetes mellitus, diabetes insipidus, hypothyroidism, or inborn errors of metabolism. - Infants known to have current or previous illnesses/conditions or intervention which could interfere with the study, such as certain medication (e.g. cortical steroids) or major surgery, as per investigator’s clinical judgement.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Prenatal and postnatal growth trajectories and prenatal maternal exposures in association with body composition at ages 1, 3, 6 and 9 months with the modification of infants nutritional intake | — |
Secondary
| Measure | Time frame |
|---|---|
| Infant’s fat mass accumulation in association with metabolic biomarkers and health parameters at the age of 3, 6, 9 months and 1 year, 18 months and 2 years, e.g. serum lipids, satiety hormones, metabolic biomarkers and body composition | — |
Contacts
Public ContactKirsten de Fluiter
Erasmus Medical Center - Sophia Childrens Hospital
Outcome results
None listed