Fluid therapy Oliguria Critically ill patients Vloeistoftherapie Oligurie Ernstig zieke patienten
Conditions
Interventions
All subjects will receive an intravenous infusion of 1500 ml of 0.9% saline during 1 hour.
Sponsors
Department of Intensive Care
Erasmus Medical Center Rotterdam
The Netherlands
Eligibility
Inclusion criteria
Inclusion criteria: 1. 18 years of age or older; 2. Informed consent; 3. Oliguria for at least 2 consecutive hours; 4. No diuretics administered in the past 3 hours.
Exclusion criteria
Exclusion criteria: 1. On continuous renal replacement therapy at time of eligibility; 2. Pregnancy; 3. Positive fluid balance ≥ 10 L at time of eligibility; 4. Risk or evidence of pulmonary edema; 5. Risk or evidence of heart failure or coronary illness; 6. pH 110 mmol/l; 7. Already included into this study more than 2 times.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Fluid responsiveness (urine output to > 0.5 ml/kg/h after fluid therapy). Timepoint: 3 hours. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Acute kidney injury, Timepoint: 28 days; 2. All-cause mortality, Timepoint: 28 days; 3. Mechnical ventilation days, Timepoint 28 days; 4. Other complications, Timepoint 28 days. | — |
Contacts
Public ContactJasper Bommel, van
PO Box 2040
Outcome results
None listed