cardiopulmonary bypass, hemodiltion, cerebral autoregulation, micro embolic signals.
Conditions
Interventions
None listed
Sponsors
Jos Maessen, MD, PhD
Maastricht University Medical Center, Dept. CTC
Phone: +31-43-3877070
Eligibility
Inclusion criteria
Inclusion criteria: 1. Elective adult candidates for CABG surgery using CPB; 2. Male gender; 3. Age: 50 -70 years old; 4. Presence of a trans-temporal bone window; 5. Informed written consent obtained by the patient.
Exclusion criteria
Exclusion criteria: 1. Patients suffering from neurological disorders (e.g. cerebrovascular accident); 2. Patients suffering from renal diseases (e.g. renal failure, defined as laboratory tests indicating values of 2 or more times the normal values [urea >= 50 U/L, kreatinine >= 170 micromol/L]); 3. Patients suffering from liver diseases, defined as laboratory tests indicating values of 2 or more times the normal values (ASAT >= 50 U/L, ALAT >= 60 U/L, LD >= 600 U/L and gamma-GT >= 90 U/L); 4. Patients suffering from severe pulmonary disorders (e.g. chronic obstructive pulmonary disease, emphysema); 5. Insulin / non insulin dependent diabetics; 6. Hypothermia during CPB; 7. Severe atherosclerosis of the carotid or the middle cerebral artery; 8. Participation in an investigational drug trial within the preceding 30 days.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To evaluate the effects of normovolemic hemodilution levels during CPB on the dynamic cerebral autoregulation and cerebrovascular reactivity. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. To evaluate the dynamic cerebral autoregulation with transcranial Doppler velocity and near infrared spectroscopy at different PaCO2 levels during normothermic CPB; 2. To evaluate the relation between PaCO2 values and the amount of micro emboli signals during CPB. | — |
Contacts
Public ContactWerner Mess
Outcome results
None listed