Diabetes Mellitus type 2
Conditions
Interventions
Physical exercise has a prominent role in the treatment of type 2 diabetes mellitus (DM2). This research project aims to improve exercise intervention programs in DM2 by validating a novel easy applic
Sponsors
Erasmus MC, Universitair Medisch Centrum Rotterdam
Afdeling Revalidatie geneeskunde / Sportgeneeskunde
Intern adres: Kamer H. 026
postbus 2040
3000 CA Rotterdam
Nederland
Eligibility
Inclusion criteria
Inclusion criteria: Substudy A: 1. Type 2 diabetes mellitus >2 yr; 2. Age: 30-80 years; 3. BMI: 27-40 kg/m2; 4. Formal permission to participate in the study by signing an informed consent form. Substudy B: 30 cases from substudy A will be included in substudy B. 1. Type 2 diabetes mellitus >2 yr; 2. Age: 35-60 years, (15 male, 15 female); 3. Formal permission to participate in the study by signing an informed consent form. 30 controls will be matched for gender and age.
Exclusion criteria
Exclusion criteria: Substudy A and B: 1. Cardiovascular disease such as heart failure, cardiac ischemia or serious peripheral vascular disease (e.g. claudicatio intermittens); 2. Serious orthopedic of neurological conditions precluding an exercise test or muscle strength test. Substudy B: 1. Use of fluoroquinolones.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Substudy A: Validating the supramaximal SteepRamp exercise test to determine physical fitness in type 2 diabetes patients by correlating the result with a conventional VO2max exercise test and determining the test-retest reliability. Substudy B: Comparing Achilles tendinosis incidence in type 2 diabetes patients with the incidence in matched controls. | — |
Secondary
| Measure | Time frame |
|---|---|
| Substudy A: 1. Develop a regression formula to predict VO2max, daily activity pattern and quadriceps strength from SteepRamp test results in type 2 diabetes patients; 2. Obtaining reference values for physical fitness, activity pattern en quadriceps strength for type 2 diabetes patients; 3. Correlating physical fitness with the level of AGE in type 2 diabetes patients. Substudy B: 1. Correlating muscle strength and activity pattern with Achilles tendon structure abnormalities in type 2 diabetes patients; 2. Correlating advanced glycation end-products (AGE) with Achilles tendon structure abnormalities in type 2 diabetes patients. | — |
Contacts
Public ContactD. Visser
P.O. box 2040
Outcome results
None listed