None listed
Conditions
Interventions
In trial A, 280 pre-menopausal women will receive either cranberry capsules (twice daily 500 mg) or standardized antibiotic treatment (once daily 480 mg trimethoprim-sulfamethoxazole = TMP/SMX).
In t
Sponsors
None listed
Eligibility
Inclusion criteria
Inclusion criteria: 1. Women aged 18 years or older; 2. At least 3 symptomatic urinary tract infections, uncomplicated or complicated, in the year preceding study inclusion OR already using any form of prophylaxis to prevent recurrences of urinary tract infections and at least 3 symptomatic urinary tract infections in the year befort the start of the prophylaxis.
Exclusion criteria
Exclusion criteria: 1. Life expectancy </= 1 year; 2. Legally incapable; 3. A renal transplant in the medical history; 4. Contraindications for or relevant interactions with TMP/SMX; 5. Additional exclusion criteria for trial A (pre-menopausal women randomized to either cranberry capsules or TMP/SMX); 6. Breastfeeding, pregnancy, or pregnancy wish for the next year; 7. Contraindications for or relevant interactions with cranberries.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. The numbers of recurrences of symptomatic UTI; 2. Time to first occurrence of antibiotic resistance in urine or faeces. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Incidence of other infections; 2. Incidence of asymptomatic bacteriuria events; 3. Quality of life; 4. Costs per prevented UTI. | — |
Contacts
Public ContactMariëlle Beerepoot
Academic Medical Center (AMC), Department of Infectious diseases, Tropical Medicine and AIDS, P.O. Box 22660
Outcome results
None listed