Metabolic syndrome, Insulin resistance, Dyslipemia, Bariatric surgery
Conditions
Interventions
none
Sponsors
Academic Medical Center (AMC), Amsterdam
Eligibility
Inclusion criteria
Inclusion criteria: - scheduled for bariatric surgery (Roux-en-Y gastric bypass) - 18-65 years of age - ability to provide informed consent - stable weight 3 months prior to inclusion - willingness to stop lipid lowering medication 4 weeks prior to studymeasurements
Exclusion criteria
Exclusion criteria: - use of exogenous insulin, GLP-1 agonists or DPP-4 inhibitors - all medica! and psychiatric conditions except for obesity-related diseases - primary lipid disorders - childhood onset obesity - coagulation disorders - uncontrolled hypertension - renal insufficiency - excessive alcohol intake - contraindication to MRI scanning
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Effect of carbohydrates (glucose and fructose) on lipogenic pathways, and the in vivo de novo lipogenesis flux in obese humans with or without hepatic steatosis and insulin resistance. | — |
Secondary
| Measure | Time frame |
|---|---|
| In vivo relationships between fat distribution/ectopic fat accumulation, lipid/carbohydrate fluxes, hepatic/peripheral insulin sensitivity, tissue lipid composition and gene/protein expression profiles. | — |
Contacts
Public ContactK.W. Horst, ter
Outcome results
None listed