Effects of a short-term high protein diet on protein metabolism and physical stress response in children after cardiac surgery.

Effects of short-term high protein intake on protein synthesis and breakdown, and stress response in children after cardiac surgery.

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON28280

Enrollment

Registered

2010-05-20

Start date

2010-07-03

Completion date

Unknown

Last updated

2024-02-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

cardiac surgery, protein energy malnutrition, stress response

Interventions

3-day, postoperative, enteral continuous drip feeding with 5 gr/kg/d protein intake (intervention group), compared to 2 gr/kg/d protein intake (control group). Both groups receive a caloric intake of

Eligibility

Inclusion criteria

Inclusion criteria: 1. Congenital heart disease (tricuspid valve atresia, pulmonary atresia, right ventricular hypoplasia) with planned surgical Glenn or Fontan procedure; 2. Extra-corporeal circuit during surgery; 3. Age: 3-48 months at time of surgery; 4. Venous and arterial access after surgery.

Exclusion criteria

Exclusion criteria: 1. Prematurity 38,5°C for > 4 hours; 5. Inotropic support other/more than: Milrinone 1,0 mcg/kg/min, Dobutamine 10 mcg/kg/min, and Norepinephrine 0,2 mcg/kg/min.

Design outcomes

Primary

Measure	Time frame
1. Total body Ra [1-13C]valine; 2. Total body valine oxidation; 3. Nonoxidative disposal valine; 4. Dndogenous Ra [1-13C]valine; 5. Valine balance; 6. Ra [15N2]urea in plasma; 7. Whole body net nitrogen retention.	—

Secondary

Measure	Time frame
Serum concentrations of: 1. Insulin; 2. Glucose; 3. Cortisol; 4. CBG; 5. IL 6-8-10; 6. CRP; 7. TNF-á.	—

Contacts

Public ContactV.G.M. Geukers

Meibergdreef 9

v.g.geukers@amc.uva.nl+31 (0)20 5665769

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)