osteoarthitis, knee, joint instability, elderly, physical functioning, pain, laxity, proprioception, muscle strength, walking. artrose, knie, gewrichtsinstabiliteit, ouderen, fysiek functioneren, pijn, laxiteit, propriocepsis, spierkracht, lopen.
Conditions
Interventions
21-12-2011 Changes:
Experimental group:
The experimental intervention comprises a 12-week exercise therapy programme aimed at:
1) improving the knee joint stabilisation process
2) muscle strengthen
Sponsors
This study will be carried out by the VU University Medical Centre (VUmc) and Jan van Breemen Institute in Amsterdam
Eligibility
Inclusion criteria
Inclusion criteria: 21-12-2011 Changes: 1. Diagnosis of knee OA according to the clinical ACR criteria, i.e.: knee pain and at least three of the following six: age > 50 years, morning stiffness <30 minutes, crepitus, bony tenderness, bony enlargement and no palpable warmth. 2. Age between 40 and 75 years. 3. Sufficient control of the Dutch language. 4. At least one of the following three criteria: * self-reported instability of the knee joint affecting daily functioning, as assessed with Fitzgerald’s knee stability questionnaire. A self-reported knee instability rating of 1 (“the symptom affects my activity mildly”) or worse is regarded to reflect knee instability affecting daily functioning * bodyweight-adjusted isokinetic hamstrings strength of 0.8 Nm/kg or less for men or 0.55 Nm/kg or less for women, in combination with a knee joint proprioception score of 4.3° or higher, as established with the instrumented knee proprioception test * bodyweight-adjusted isokinetic hamstrings strength of 0.8 Nm/kg or less for men or 0.55 Nm/kg or less for women, in combination with a knee joint laxity score of 4.6° or higher for men or 7.7° or higher for women, as established with the instrumented knee laxity test
Exclusion criteria
Exclusion criteria: 1. Co-morbidity which clearly affects functional ability.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 21-12-2011 Changes: The primary outcome measure in this RCT is self-reported physical functioning as assessed with the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC). | — |
Secondary
| Measure | Time frame |
|---|---|
| 21-12-2011 Changes: A number of secondary outcome measures are included in the study, reflecting both the assessment of disabilities in specific daily activities, the patient perspective, and relevant biomechanical factors. These measures are: - perceived global effect (7-point Likert scale) - pain intensity (0-10 NRS) - stiffness (WOMAC) - fatigue (0-10 NRS) - Fitzgerald’s self-reported knee joint instability scale - proprioception - laxity - isokinetic muscle strength of the upper leg (BioDex) - frontal plane alignment of the knee (goniometer) - observed walking and transfer ability as assessed with the Get Up and Go (GUG) test | — |
Contacts
Public ContactM.P.M. (Martijn) Steultjens
VU University Medical Center, Department of Rehabilitation, Occupational and Physical Therapy, P.O. Box 7057
Outcome results
None listed