Non-Alcoholic Steatohepatitis (NASH), Non-Alcoholic Fatty Liver Disease (NAFLD), Obesity, Paediatrics, Hepatic Steatosis, FibroScan, 1H-MR Spectroscopy Proton Density Fat Fraction (MRS-PDFF)
Conditions
Interventions
None listed
Sponsors
Amsterdam UMC, location AMC, Department of Radiology & Nuclear Medicine
Eligibility
Inclusion criteria
Inclusion criteria: - Written informed consent from parent(s) and subject (when >12 years of age) - For current patients: • Clinically suspected or high risk profile of hepatic steatosis based on at least one of the following: - abnormal echogenicity of liver in ultrasonography; - elevated serum transaminases levels; - high BMI (>+3 z-score) and/or waist circumference (>95 percentile); - insulin resistance. - For patients no longer in active follow-up: • Liver steatosis detected during follow-up in this clinic in the last 3 years
Exclusion criteria
Exclusion criteria: - Age 18 years - The need for anaesthesia during the MRI examination. - General contra-indications for MRI scanning (use of MRI checklist, see document E4) - Known focal liver lesion(s) in the right liver lobe (proven with histology results or imaging) - Known concomitant liver disorders
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Diagnostic accuracies of CAP and US for the detection of hepatic steatosis using 1H-MR Spectroscopy derived proton density fat fraction (MRS-PDFF) as reference standard. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Inter- and intraobserver variability for CAP-values; 2. Success rate of CAP-measurements; 3. Correlation between CAP-values and fat percentage at MRI-based liver fatmaps. | — |
Contacts
Public ContactJurgen Runge
Amsterdam UMC, location AMC, Department of Radiology & Nuclear Medicine
Outcome results
None listed