adult onset asthma phenotyping markers
Conditions
Interventions
Not applicable, observational study.
Sponsors
Academic Medical centre
Eligibility
Inclusion criteria
Inclusion criteria: 1. 18 to 75 years; 2. Adult-onset asthma (i.e. asthma that started after the age of 18); 3. Physicians diagnosis of asthma 12 % predicted and 200 ml or airway hyperresponsiveness to inhaled methacholine (PC20 25% reduction in oral or inhaled corticosteroid dose (within 4 weeks).
Exclusion criteria
Exclusion criteria: 1. Patients with smoking history > 10 packyears, who have fixed airflow obstruction (post bronchodilator FEV1 12 % predicted and 200 ml; 2. Pregnancy; 3. Physician's diagnosis of asthma in childhood; 4. Other pulmonary diseases or non-related major-comorbidities; 5. Episodes of severe dypneu in childhood (age 5-12 yr); 6. Diffusion capacity < 80% (TLCO/VA).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Phase 1: Cross-sectional assessment. 3-4 separate subtypes will be defined by cluster analysis; risk factors of severe disease and poor quality of life will be defined. Phase 2: Follow-up during 4 years. The cohort of patients will be prospectively followed for 4 years. The course of the disease during treatment by their own physician/ pulmonologist will be observed. Potential risk factors will be assessed at baseline (patients’ clinical characteristics, different non-invasive markers of airway inflammation, lungfunction, airway hyperresponsiveness) and related to the change in lung function and exacerbation rate over time. | — |
Contacts
Public ContactS.B. Nijs, de
Dept. Pulmonology Academic Medical Center (C2-435) Meibergdreef 9
Outcome results
None listed