Exploring the value of novel synovial fluid biomarkers to improve the diagnosis of patients with periprosthetic hip and knee joint infections.

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON28263

Enrollment

500

Registered

2020-05-07

Start date

2020-08-01

Completion date

Unknown

Last updated

2024-02-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Revision of Total Hip Arthroplasty or Total Knee Arthroplasty

Interventions

None listed

Eligibility

Inclusion criteria

Inclusion criteria: All hospital patients planned for elective revision surgery due to failure/loosening of their THA or TKA implant will be eligible for participation provided they are willing and able to give their consent for use of their their human tissues for medical/scientific research.

Exclusion criteria

Exclusion criteria: Patients will be excluded from participation if they are planned for revision surgery due to suspected arthroplasty dislocation or malpositioning, have received intravenous and/or oral antibiotics within two weeks before the diagnostic workup, or if they have a diagnosis of a systemic inflammatory disease.

Design outcomes

Primary

Measure	Time frame
The value of flow cytometry analysis of synovial fluid as a diagnostic tool for diagnosing PJI in terms of validity, sensitivity and specificity when added to the current diagnostic scoring system (and compared to using the current diagnostic scoring system without this novel method).	—

Contacts

Public ContactL.D. de Jong

Rijnstate Hospital

lddejong@rijnstate.nl0880058275

Outcome results