The effect of doxycycline on Matrix Metalloproteinase expression and activity in the abdominal aneurysm.

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON28262

Enrollment

Registered

2008-01-30

Start date

2000-12-01

Completion date

Unknown

Last updated

2024-02-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Abdominal aortic aneurysm Aneurysma van de abdominale aorta

Interventions

none (control) doxycyline 50 mg oid, 2 weeks doxycyline 100 mg oid, 2 weeks doxycyline 300 mg oid, 2 weeks

Eligibility

Inclusion criteria

Inclusion criteria: Indication for open aneurysm repair.

Exclusion criteria

Exclusion criteria: Impaired kidney and or liver dysfunction doxycycline intolerance.

Design outcomes

Primary

Measure	Time frame
MMP-1, 8, 13 mRNA and protein expression.	—

Secondary

Measure	Time frame
Cathepsin K,L and S mRNA protein expression, expression of other MMPs and the respective inhibitors.	—

Contacts

Public ContactJan H. Lindeman

Leiden University Medical Center Dpt. of Vascular Surgery. PO-box 9600

Lindeman@lumc.nl

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)