The effect of weight loss through a low calory diet on exercise induced asthma in children with asthma and moderate overweight.

The effect of weight loss through a low calory diet on exercise induced bronchoconstriction in children with asthma and moderate overweight.

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON28255

Enrollment

Registered

2010-11-29

Start date

2010-12-13

Completion date

Unknown

Last updated

2025-03-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Overweight and exercise induced asthma in children. Dutch: Overgewicht en inspanningsastma bij kinderen.

Interventions

All children will follow a low calory diet for 6 weeks in order to lose weight. After that period we measure the change in BMI.

Eligibility

Inclusion criteria

Inclusion criteria: 1. Age between 8-18 years; 2. Doctors diagnosis of mild to moderate asthma; 3. Exercise induced asthma defined by a >10% exercise induced fall in FEV1; 4. BMI score above or at the cut off points for overweight, based on international data and linked to the widely accepted adult cut off points of a body mass index of 25 kg/m2; 5. Clinically stable period at least 3 weeks before the study period; 6. Maximal FEV1 >70% of predicted value.

Exclusion criteria

Exclusion criteria: 1. Other pulmonary or cardiovascular illnesses; 2. Genetic disorders; 3. Maximal FEV1 <70% of predicted value; 4. Use of long acting bronchodilators 24 hours before testing; 5. Use of short acting bronchodilators 8 hours before testing.

Design outcomes

Primary

Measure	Time frame
Analyze the relation between the reduction in BMI and the reduction in exercise induced fall in FEV1, after a diet-period of 6 weeks. We measure the exercise induced fall in FEV1 with an exercise provocation test before and after the diet.	—

Secondary

Measure	Time frame
Secondary we analyze the relation between reduction in BMI and the recovery of the lungfunction to baseline, the increase in baseline FEV1, the reduction in FeNO, quality of life and the asthma control.	—

Contacts

Public ContactMira Hoogstrate

Postbus 50.000

m.c.hoogstrate@student.rug.nl+31 (0)53 4872310

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)