The calcification propensity of uremic patients on hemodialysis.

Effect of calcium and citrate dialysate concentrations on the calcification propensity in hemodialysis; a prospective randomized controlled cross-over trial.

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON28230

Enrollment

Registered

2015-04-23

Start date

2017-04-28

Completion date

Unknown

Last updated

2025-03-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Calcification propensity. Dialysis. Vascular Calcification.

Interventions

Change in dialysate calcium concentration and using calcium-citrate dialysate.

Eligibility

Inclusion criteria

Inclusion criteria: Prevalent HD patients with a dialysis vintage of at least 3 months. Hemodynamically stable on dialysis. AV-fistula enabling double-needle vascular access with a blood flow rate of at least 300 ml/min. Age above 18 years of age. Informed consent.

Exclusion criteria

Exclusion criteria: Withdrawal of consent Acute intercurrent illness (infection, malignancy, cardiovascular event, uncontrolled diabetes) Long QT syndrome Frequent intra-dialytic hypotension (>10% of treatments)

Design outcomes

Primary

Measure	Time frame
Calcification propensity of the serum measured by the transformation time from primary to secondary calciprotein particles (T50).	—

Secondary

Measure	Time frame
Increased vascular velocity measured by a pulse wave velocity meter.	—

Contacts

Public ContactMarijke Dekker

Department of Internal Medicine, division of Nephrology. - Catharina Hospital Eindhoven

marijke.dekker@mumc.nl

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)