movement disorders diagnosis closed-loop approach fMRI
Conditions
Interventions
None listed
Sponsors
Academic Medical Center
University of Amsterdam
PO-box: 22660
1100 DD Amsterdam
Tel: +31 (0)20.5669111
Eligibility
Inclusion criteria
Inclusion criteria: 1. 18 years or older; 2. Right-handed according to the Edinburgh Handedness Inventory; 3. Willingness to stop medication intake for eight hours prior to investigations. And either: 1. Essential tremor according to criteria defined by the Tremor Investigation Group, moderate to severe tremor (Tremor Rating Scale Part A 2 UE>2); 2. Hereditary ET (positive family history: at least one affected relative in immediate family; Onset in patient and family member before age 65); 3. Positive effect of propranolol on tremor; 4. Parkinson’s disease according to the UK Brain Bank criteria for Parkinson’s disease; 5. No major fluctuations in symptoms due to medication; 6. No severe dyskinesia; 7. Limb dystonia with at least 35 points on the motoric part of the Burke-Fahn-Marsden Dystonia Rating Scale; 8. Healthy age and sex-matched controls.
Exclusion criteria
Exclusion criteria: 1. MR-incompatible implanted metal bodies, including stereotactic implant for Deep Brain Stimulation and pacemakers; 2. Other contraindications for MR (Claustrophobia, obesity, etc.); 3. Use of medicines/drugs that could influence the performance during the tasks (such as anti-epileptic drugs, neurodepressants, etc.); 4. Pregnancy or suspected pregnancy; 5. Incapability to give informed consent; 6. Other neurological disorder than ET/PD-T/dystonia including dementia; 7. Abnormalities of the hand/wrist or prior surgery of the hand/wrist.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Differentiation between ET, PD-T and DYS based on brain activations specifically related to involuntary movements. With external measures and perturbation of the closed sensorimotor loop during fMRI we expect to find involvement of the olivocerbellar networks in ET, the striatum in PD-T and a widespread involvement of basal ganglia, thalamus, and cerebral cortex in dystonia. | — |
Secondary
| Measure | Time frame |
|---|---|
| Observation and identification of the brain regions involved in (the early stages) of movement disorders with overlapping symptoms will contribute to the knowledge on the occurrences and causes of these diseases on a more fundamental level. | — |
Contacts
Public ContactS. Sharifi
Academic Medical Center, University of Amsterdam
Outcome results
None listed