QT-prolongation, cardiac dysrythmias
Conditions
Interventions
None. It concerns an observational study.
Domperidone is prescribed as part of usual care.
Sponsors
Erasmus MC
Eligibility
Inclusion criteria
Inclusion criteria: - new prescription of domperidone while hospitalised in the Erasmus Medical Center - age 18 years and older
Exclusion criteria
Exclusion criteria: - no informed consent - terminally ill patient - incompetent patient - congenital prolonged QT-syndrome
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| QT-time on ECG performed 30-60 minutes after the fourth dosage of domperidone. | — |
Secondary
| Measure | Time frame |
|---|---|
| QT-time on 24 hour (continuous) ECG Several characteristics will be collected in order to establish the potential association of these characteristics with the primary outcome: - serum concentration of domperidone 30-60 minutes after the fourth dosage of domperidone - pharmacogenetics (CYP3A4, CYP1A2, CYP2E1) - general patient characteristics (age, gender, body weight, comorbidities, renal and hepatic function, serum electrolyte parameters) - domperidone dosage - comedication. | — |
Contacts
Public ContactP.M.L.A. Bemt, van den
Erasmus MC Hospital Pharmacy P.O. Box 2040
Outcome results
None listed