Regulation of adipose tissue oxygen tension by adipose tissue blood flow.

Adipose tissue hypoxia in the pathogenesis of type 2 diabetes.

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON28187

Enrollment

Registered

2010-08-02

Start date

2009-06-17

Completion date

Unknown

Last updated

2024-02-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Diabetes Mellitus, Insulin resistance, Adipose tissue blood flow, Adipose tissue hypoxia

Interventions

Adipose tissue oxygen tension will be measured using an optochemical measurement system for the continuous monitoring of oxygen tension in vivo in humans using microdialysis. Adipose tissue oxygen ten

Eligibility

Inclusion criteria

Inclusion criteria: 1. Male sex; 2. BMI < 25 kg/m2; 3. Age 25-70 yrs; 4. Weigth stable for at least 3 months prior to participation; 5. Normal glucose tolerant (NGT); 6. No family history of type 2 diabetes mellitus (first degree).

Exclusion criteria

Exclusion criteria: 1. Diabetes mellitus; 2. Cardiovascular disease; 3. Cancer; 4. Asthma or bronchitis; 5. Liver or kidney malfunction; 6. Disease with a life expectancy shorter then 5 years; 7. Abuse of products (alcohol consumption > 15 units/week); 8. Plans to lose weight; 9. Use of high doses of anti-oxidant vitamins; 10. Use of any medication that influences glucose metabolism and/or inflammation.

Design outcomes

Primary

Measure	Time frame
Primary outcoem parameters are adipose tissue blood flow and adipose tissue oxygen tension.	—

Secondary

Measure	Time frame
Secondary outcoem parameters are insulin sensitivity, gene expression and adipocyte size.	—

Contacts

Public ContactG.H. Goossens

PO Box 616

G.Goossens@hb.unimaas.nl+31 (0)43 3881314

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)