anxiety disorders
Conditions
Interventions
Cannabidiol (synthetic) in ethanol solution, inhaled via a vaporizer
Sponsors
Utrecht University (UU)
Eligibility
Inclusion criteria
Inclusion criteria: - Male or female volunteers between 18 and 40 years. - Judged to be in good physical and mental health on the basis of the medical history according to self-report. - Have a normal binocular acuity, corrected or uncorrected. - Female participants must declare they are on reliable birth control.
Exclusion criteria
Exclusion criteria: A potential subject who meets any of the following criteria will be excluded from participation in this study: - Have a history of any disease, e.g. neurological disorders, psychiatric disorders, which in the opinion of the investigator may confound the results of the study. - Present any other conditions in that in the investigators’, the subjects’ personal or the physicians’ opinion may confound the results of the study. - History of psychotic disorder/psychosis and/or having a first/second degree family member with (a history of) psychotic disorder/psychosis. - Current diagnosis of an Axis I or Axis II psychiatric disorder, or suffering from an Axis I or Axis II psychiatric disorder within 4 weeks prior to the study. - Current respiratory disease or history of respiratory disease. - Current asthma or history of asthma. - Acute cardiac disease and/or history of cardiac disease. -  History of abuse or current regular use of cannabis more than once a week. -  Have been using psychoactive drugs in the four weeks prior to the study. - Known hypersensitivity to CBD. - Exposed to cannabinoids with adverse reactions. - Have a history of severe allergy or general drug hypersensitivity. -  Current drug use or indications, from urine screening, of current drug use. - History of epilepsy. - Reduced startle activity, defined as no discernible response in at least 3 startle stimuli presented at screening. - Pregnancy, i.e., a positive β-HCG urine test. - Lactating. 
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Both subjective and objective parameters pertaining to fear conditioning and fear extinction will be assessed, the main physiological measure is the fear potentiated startle reflex. | — |
Secondary
| Measure | Time frame |
|---|---|
| Questionnaires, skin conductance responses. | — |
Contacts
Public ContactIvo Heitland
Utrecht University, Department of Experimental Psychology
Outcome results
None listed