Parkinson's disease
Conditions
Interventions
None listed
Sponsors
UMCG
Eligibility
Inclusion criteria
Inclusion criteria: - Willingness to cooperate and sign written informed consent Patients: - Clinical diagnosis of idiopathic Parkinson’s disease by a neurologist with disease duration between 5 and 15 years.
Exclusion criteria
Exclusion criteria: - Incapable to provide informed consent (e.g. in case of severe dementia) - Treatment with drugs with anticholinergic activity, as listed in Chew et al. 2008 and Ehrt et al. 2010 - Current or recent treatment with ChEIs - Presence of deep brain stimulation implants - (Suspected) pregnancy - Migraine - Epilepsy - Participation in a scientific research study during the past year involving radiation - MRI contra-indications, e.g. o Ferrous objects in or around the body (e.g. braces, pacemaker, metal fragments) o Claustrophobia - Insufficient knowledge of the Dutch language Control subjects: - History of neurological or neurodegenerative disorder Patients: - Moderate to severe cognitive impairment, but no dementia, according to diagnostic criteria PD-D: - Unsafe or irresponsible to postpone treatment with ChEIs, according to treatment provider
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The main study parameter is the relationship between baseline SAI and [18F]FEOBV PET imaging. | — |
Secondary
| Measure | Time frame |
|---|---|
| - Tracer binding in different regions of interest (ROIs) and per voxel. - Outcome of all questionnaires and clinical tests. | — |
Contacts
Public ContactEmile d'Angremont
Universitair Medisch Centrum Groningen
Outcome results
None listed