AECOPD (Acute exacerbation of COPD) inhalation nebulization antibiotics amoxicillin
Conditions
Interventions
The included patient will be given amoxicillin clavulanic acid by inhalation twice daily in a fixed dose. (for 3 days)
Sponsors
Medisch Spectrum Twente (Medical Center)
Eligibility
Inclusion criteria
Inclusion criteria: 1) A clinical diagnosis of COPD, as defined by GOLD criteria 2) Hospitalized for an acute exacerbation of COPD 3) Admitted to the ward of pulmonary medicine 4) Age 40 years or over 5) Current or former smoker
Exclusion criteria
Exclusion criteria: 1) Current pneumonia, defined as an acute respiratory tract illness associated with radiographic shadowing on a X-ray or CT-scan of the chest which was neither pre-existing nor of any other cause. 2) Allergy for penicillin, amoxicillin or clavulanic acid. 3) Recently diagnosed or unresolved lung malignancy 4) amoxicillin or clavulanic acid therapy within 3 days prior to admission During the trial the patient cannot be treated with systemic amoxicillin or amoxicillin clavulanic acid.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Dose exposure data as determined by sputum concentrations of amoxicillin. Amoxicillin levels in sputum give information on the appropriateness of the dose given from a calculated time > MIC. | — |
Secondary
| Measure | Time frame |
|---|---|
| The safety and tolerability of inhalation of nebulized amoxicillin clavulanic acid by adverse effects monitoring. | — |
Contacts
Public ContactP.D.L.P.M. Valk, van der
Medisch Spectrum Twente Hospital Department of Pulmonology PO Box 50.000
Outcome results
None listed