Diagnosis, Pulmonary embolism, pregnancy
Conditions
Interventions
Prospective multicenter management study of consecutive pregnant patients with suspected (recurrent) PE. Participants will be evaluated according to the study algorithm consisting of three items of th
1 items and a D-dimer level < 0.5 µg/ml PE is excluded without computed tomography pulmonary angiography (CTPA). In the other patients a CTPA will be performed. If PE is confirmed by CTPA, anticoagula
Sponsors
Leiden University Medical Center (LUMC)
Eligibility
Inclusion criteria
Inclusion criteria: - Pregnant patient with suspected (recurrent) pulmonary embolism - age ¡Ý 18 years
Exclusion criteria
Exclusion criteria: - treatment with full-dose therapeutic low molecular weight heparin or unfractionated heparin that was initiated 24 hours or more prior to eligibility assessment - treatment with vitamin K antagonists (coumarin derivates) - Ultrasonography proven symptomatic proximal DVT - unable to give consent - contraindication to helical CT because of allergy to intravenous iodinated contrast or renal insufficiency (creatinin clearance < 30 ml/min) - impossibility to return for follow-up - life expectancy < 3 months
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| (recurrent) PE, DVT, mortality | — |
Secondary
| Measure | Time frame |
|---|---|
| number of performed CTPAs | — |
Contacts
Public ContactL.M. van der Pol
Department of Thrombosis and Haemostasis Leiden University Medical Cente
Outcome results
None listed