Obesity, dietary proteins, oral administration, duodenal administration, satiety
Conditions
Interventions
This study is a randomized, placebo controlled cross-over study with 2 groups of volunteers. One group will consist of healthy lean male subjects. The other group will consist of obese male subjects.
Sponsors
Transnational University Limburg
Eligibility
Inclusion criteria
Inclusion criteria: 1. Male, non smoking 2. Age between 18 and 65 years 3. Body Mass Index for lean subjects between 20 and 26 kg/m2 4. Body Mass Index for obese subjects between 30 and 37 kg/m2 5. No medication 6. No history of intestinal illness 7. Stable body weight over the last three months 8. No blood donation 2 months prior to the study and during the study
Exclusion criteria
Exclusion criteria: 1. Age under 18 and over 65 years 2. BMI under 20 and over 37 kg/m2 3. Medication or disease that could interfere with the results of the study, to be judged by the responsible medical doctor 4. Recent blood donation within 2 months prior to the start of the study 5. Intestinal illness at any time in the past 6. Female 7. Smokers
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The effects of orally- and intraduodenally administered intact protein on systemic satiety hormone levels (CCK, GLP-1, and PYY) and feelings of hunger and satiety | — |
Secondary
| Measure | Time frame |
|---|---|
| - To investigate the differences in plasma hormone levels after protein exposure in lean vs. obese subjects - To investigate whether duodenal protein supplementation reduces food intake compared to oral supplementation | — |
Contacts
Public ContactM.C.P. Geraedts
University of Maastricht PO Box 616
Outcome results
None listed