Brain metastases
Conditions
Interventions
Patients will complete a standardized battery of neuropsychological test both at baseline
and 3, 6, 9, 12, 15, and 21 months post GKRS.
Sponsors
St Elisabeth Hospital, Tilburg and Tilburg University
Eligibility
Inclusion criteria
Inclusion criteria: 28-okt-2016: • Histologically proven malignant cancer • Imaging and clinical presentation consistent with BM; contrast enhanced volumetric MRI used for treatment planning showing 1-10 newly diagnosed BM with a maximum total tumor volume of 30 cm3 • Lesion >3mm from brainstem or optic apparatus • Patient age >/=18 years • Karnofsky Performance Status ≥70 • WHO performance status ≤2 • Anticipated survival (independent of the BM) greater than 3 months • Patient informed consent obtained (verifying that patients are aware of the investigational nature of this study).
Exclusion criteria
Exclusion criteria: 28-okt-2016: • No prior histologic confirmation of malignancy • Primary brain tumor, a second (active) primary tumor • Lymphoma • Small cell lung cancer • Leukemia • Meningeal disease • Progressive, symptomatic systemic disease without further treatment options • Prior brain radiation • Prior surgical resection of BM • Additional history of a significant neurological or psychiatric disorder • Participation in a concurrent study in which neuropsychological testing and/or health-related QOL assessments are involved • Contra indications to MRI or gadolinium contrast • Underlying medical condition precluding adequate follow-up • Lack of informed consent • Patients unable to complete test battery and/or study questionnaires due to any of the following reasons; lack of basic proficiency in Dutch, IQ below 85, severe aphasia and paralysis grade 0-3 according to MRC scale (Medical Research Council
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Cognitive functioning will be examined with a battery of neuropsychological tests: The revised Hopkins Verbal Learning Test (HVLT-R), WAIS Digit Span and Digit Symbol, TMT A and B, COWA, and Grooved Pegboard. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1) Fatigue (MFI) 2) Health related QOL (FACT-BR) 3) Depression and anxiety (HADS) 4) Overall Survival 5) Local and distant tumor control | — |
Contacts
Public ContactKarin Gehring
Tilburg University - department of Cognitive Neuropsychology - Simon building - room S 219
Outcome results
None listed